Fragment inédit de l’Océantume

De novo centromere formation on a chromosome fragment in maize.

The centromere is the part of the chromosome that organizes the kinetochore, which mediates chromosome movement during mitosis and meiosis. A small fragment from chromosome 3, named Duplication 3a (Dp3a), was described from UV-irradiated materials by Stadler and Roman in the 1940s [Stadler LJ, Roman H (1948) Genetics 33(3):273-303]. The genetic behavior of Dp3a is reminiscent of a ring chromoso...

GroupBuild: a fragment-based method for de novo drug design.

A novel method for de novo drug design, GroupBuild, has been developed to suggest chemically reasonable structures which fill the active sites of enzymes. The proposed molecules provide good steric and electrostatic contact with the enzyme and exist in low-energy conformations. These structures are composed entirely of individual functional groups (also known as "building blocks" or "fragments"...

Fragment-Based de Novo Ligand Design by Multiobjective Evolutionary Optimization

GANDI (Genetic Algorithm-based de Novo Design of Inhibitors) is a computational tool for automatic fragment-based design of molecules within a protein binding site of known structure. A genetic algorithm and a tabu search act in concert to join predocked fragments with a user-supplied list of fragments. A novel feature of GANDI is the simultaneous optimization of force field energy and a term e...

Fragment 3 Asserted Fragment 2 Asserted Fragment 1 Asserted Assertion F 3 F 1 F 2 Invariant Tuple Space Fragment 3 Fragment 2 Fragment 1 Fragmentation Mapping

Vaccination antirougeoleuse: Etude de l'immunité humorale chez les enfants Vaccinés de la région de Tunis